Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy
نویسندگان
چکیده
منابع مشابه
Arterial input function measurement without blood sampling using a beta-microprobe in rats.
UNLABELLED The evaluation of every new radiotracer involves pharmacokinetic studies on small animals to determine its biodistribution and local kinetics. To extract relevant biochemical information, time-activity curves for the regions of interest are mathematically modeled on the basis of compartmental models that require knowledge of the time course of the tracer concentration in plasma. Such...
متن کاملLactate measurement: arterial versus venous blood sampling
Lactate is the end product of the metabolic process of glucose utilization, known as anaerobic glycolysis, which occurs in the cytoplasm of all cells. In well-oxygenated tissues this lactate is metabolized further, but if tissues are inadequately oxygenated, lactate accumulates locally and blood concentration increases. As a blood marker of tissue hypoxia, lactate measurement has long-establish...
متن کاملQuantitative myocardial perfusion imaging using a step arterial-input function
Background Modern MRI myocardial perfusion protocols use rapid venous bolus injections, typically 3-5 ml/s of 5-15 ml of agent over a few seconds. The resulting arterial input functions are rapidly varying with high agent concentrations (Fig. 1A and 1B) and thus typically require high temporal resolution acquisitions (~1 sec), custom pulse sequences and complex processing methods for perfusion ...
متن کاملQuantitative Amyloid Imaging Using Image-Derived Arterial Input Function
Amyloid PET imaging is an indispensable tool widely used in the investigation, diagnosis and monitoring of Alzheimer's disease (AD). Currently, a reference region based approach is used as the mainstream quantification technique for amyloid imaging. This approach assumes the reference region is amyloid free and has the same tracer influx and washout kinetics as the regions of interest. However,...
متن کاملMeasurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis
Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small animal PET systems use stationary detector gantries, thus affording high temporal resolution imaging of cardiac function. Systems designed to maximize spatial resolution and detection sensitivity employing rotating gantry designs are subop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EJNMMI Physics
سال: 2020
ISSN: 2197-7364
DOI: 10.1186/s40658-020-0277-4